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Title: Pericine  
Author: World Heritage Encyclopedia
Language: English
Subject: List of opioids, Hydrocodone, Kobret, 6β-Naltrexol-d4, Hemorphin
Collection: Alkaloids Found in Apocynaceae, Azocines, Heterocyclic Compounds (Bridged-Ring), Indole Alkaloids, Mu-Opioid Agonists, Opioids
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
  • Legal
Routes Oral
CAS number  YesY
ATC code None
Chemical data
Formula C19H22N2 
Mol. mass 278.391 g/mol

Pericine is one of a number of indole alkaloids found in the tree Picralima nitida, commonly known as Akuamma. The dried seeds from this plant are used in traditional medicine throughout West Africa, particularly in Ghana as well as in the Ivory Coast and Nigeria. As with some other alkaloids from this plant such as akuammine, pericine has been shown to bind to mu opioid receptors, and has an IC50 of 0.6 μmol, around 6x more potent than codeine when tested in the same assay.[1] However it may also have convulsant effects.[2]

See also


  1. ^ Arens, H.; Borbe, H. O.; Ulbrich, B.; Stöckigt, J. (Dec 1982). "Detection of Pericine, a New CNS-active Indole Alkaloid from Picralima nitida Cell Suspension Culture by Opiate Receptor Binding Studies". Planta Medica 46 (12): 210–214.  
  2. ^ Roberts, M. F.; Wink, M. Alkaloids: Biochemistry, Ecology, and Medicinal Applications. pp. 68–69.  

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