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Phencyclamine

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Title: Phencyclamine  
Author: World Heritage Encyclopedia
Language: English
Subject: Glycine, Heptaminol, 2-Propanoyl-3-(4-isopropylphenyl)-tropane, Isoethcathinone, TC-2216
Collection: Amines, Designer Drugs, Dissociative Drugs
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Phencyclamine

Phencyclamine
Systematic (IUPAC) name
N-(1-phenylcyclohexyl)propanamine
Clinical data
Legal status
?
Identifiers
CAS number
ATC code None
ChemSpider  YesY
Chemical data
Formula C15H23N 
Mol. mass 217.349 g/mol
 YesY   

Phencyclamine or PCPr is a dissociative anesthetic drug with hallucinogenic and sedative effects. It is around the same potency as phencyclidine, although slightly less potent than its ethyl homologue eticyclidine,[1] and has reportedly been sold as a designer drug in Germany and other European countries since the late 1990s.[2][3]

Several other related derivatives have also been encountered, with the n-propyl group of PCPr replaced by 2-methoxyethyl, 2-ethoxyethyl or 3-methoxypropyl groups to form PCMEA, PCEEA and PCMPA respectively.[4][5][6]

PCMEA, PCEEA and PCMPA


See also

References

  1. ^ MADDOX VH, GODEFROI EF, PARCELL RF (March 1965). "THE SYNTHESIS OF PHENCYCLIDINE AND OTHER 1-ARYLCYCLOHEXYLAMINES". Journal of Medicinal Chemistry 8: 230–5.  
  2. ^ Sauer C, Peters FT, Staack RF, Fritschi G, Maurer HH (April 2008). "Metabolism and toxicological detection of a new designer drug, N-(1-phenylcyclohexyl)propanamine, in rat urine using gas chromatography-mass spectrometry". Journal of Chromatography A 1186 (1-2): 380–90.  
  3. ^ Christoph Sauer. Phencyclidine Derivatives – A new Class of Designer Drugs. Studies on the Metabolism and Toxicological Analysis. Universität des Saarlandes, 2008
  4. ^ Sauer C, Peters FT, Staack RF, Fritschi G, Maurer HH (March 2008). "New designer drugs N-(1-phenylcyclohexyl)-2-ethoxyethanamine (PCEEA) and N-(1-phenylcyclohexyl)-2-methoxyethanamine (PCMEA): Studies on their metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques". Journal of Mass Spectrometry : JMS 43 (3): 305–16.  
  5. ^ Sauer C, Peters FT, Schwaninger AE, Meyer MR, Maurer HH (February 2009). "Investigations on the cytochrome P450 (CYP) isoenzymes involved in the metabolism of the designer drugs N-(1-phenyl cyclohexyl)-2-ethoxyethanamine and N-(1-phenylcyclohexyl)-2-methoxyethanamine".  
  6. ^ Sauer C, Peters FT, Staack RF, Fritschi G, Maurer HH (October 2008). "Metabolism and toxicological detection of the designer drug N-(1-phenylcyclohexyl)-3-methoxypropanamine (PCMPA) in rat urine using gas chromatography-mass spectrometry". Forensic Science International 181 (1-3): 47–51.  
GABAA
agonists/PAMs
Alcohols:
Barbiturates:
Benzodiazepines:
Carbamates:
Neuroactive Steroids:
Nonbenzodiazepines:
Phenols:
Piperidinediones:
Quinazolinones:
Volatiles/gases
Others:
GABAB
agonists
H1 inverse
agonists
Antihistamines:
Antidepressants
Antipsychotics
α1-Adrenergic
antagonists
Antidepressants
Antipsychotics
Others:
α2-Adrenergic
agonists
5-HT2A
antagonists
Antidepressants
Antipsychotics
Others:
Melatonin
agonists
Orexin
antagonists
Others


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