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Title: Dasotraline  
Author: World Heritage Encyclopedia
Language: English
Subject: Serotonin–norepinephrine–dopamine reuptake inhibitor, Benzyl cyanide
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
CAS number
ATC code ?
ChemSpider  N
Chemical data
Formula C16H15Cl2N 

Dasotraline (INN;[1] SEP-225,289) is an antidepressant drug, which was being developed by Sepracor. It is a so-called triple reuptake inhibitor (TRI).[2][3][4][5]


  1. ^ "WHO Drug Information, Vol. 27, No. 4, 2013 Proposed INN: List 110". WHO. Retrieved 4 November 2014. 
  2. ^ Chen Z, Skolnick P (September 2007). "Triple uptake inhibitors: therapeutic potential in depression and beyond". Expert Opin Investig Drugs 16 (9): 1365–77. PMID 17714023. doi:10.1517/13543784.16.9.1365. 
  3. ^ DeLorenzo C, Lichenstein S, Schaefer K, Dunn J, Marshall R, Organisak L, Kharidia J, Robertson B, Mann JJ, Parsey RV (July 2011). "SEP-225289 serotonin and dopamine transporter occupancy: a PET study". J. Nucl. Med. 52 (7): 1150–5. PMC 3856248. PMID 21680689. doi:10.2967/jnumed.110.084525. 
  4. ^ Ziegler, L.; Küffer, G.; Euler, E.; Wilhelm, K. (1990). "Arthrographic imaging of ganglions of the hand". RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 153 (2): 143–146. PMID 2168068. doi:10.1055/s-2008-1033352. 
  5. ^ Guiard, B. (2009). "P.1.c.059 Electrophysiological properties of the triple reuptake inhibitor SEP 225289 on monoaminergic neurons". European Neuropsychopharmacology 19: S285. doi:10.1016/S0924-977X(09)70419-5. 

Further reading

Liming Shao Patent
  • US application 2007203111, Shao L, Wang F, Malcolm SC, Hewitt MC, Bush LR, Ma J, Varney MA, Campbell U, Engel SR, Hardy LW, Koch P, Campbell JE, "Cycloalkylamines as monoamine reuptake inhibitors", published 2007-08-30, assigned to Sepracor Inc. 
Asymmetry Patent
  • US patent 7129378, Han X, Krishnamurthy D, Senanayake CH, Lu Z-H, "Method of preparing amine stereoisomers", published 2005-07-28, assigned to Apsinterm LLC 

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