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Dasotraline (INN;[1] SEP-225,289) is an antidepressant drug, which was being developed by Sepracor. It is a so-called triple reuptake inhibitor (TRI).[2][3][4][5]
* Note that many TCAs, TeCAs, antipsychotics, ergolines, and some piperazines like buspirone and trazodone all antagonize α1-adrenergic receptors as well, which contributes to their side effects such as orthostatic hypotension.
* Note that many atypical antipsychotics and azapirones like buspirone (via metabolite 1-PP) antagonize α2-adrenergic receptors as well.
* Note that MAO-B inhibitors also influence norepinephrine/epinephrine levels since they inhibit the breakdown of their precursor dopamine.
Cocaine, Iron, Zinc, Lysergic acid diethylamide, 5-Carboxamidotryptamine