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Title: Slc39a1  
Author: World Heritage Encyclopedia
Language: English
Subject: Solute carrier family, Prostate cancer, SLC2A13, SLC2A14, SLC35C1
Publisher: World Heritage Encyclopedia


Solute carrier family 39 (zinc transporter), member 1
Symbols  ; ZIP1; ZIRTL
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.[1] [2][3]

The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.[4]

See also


  1. ^ Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics 62 (2): 272–80.  
  2. ^ Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem 275 (8): 5560–4.  
  3. ^ "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1". 
  4. ^ Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer 5: 17.  

Further reading

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