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Title: Sabcomeline  
Author: World Heritage Encyclopedia
Language: English
Subject: Milameline, Alvameline, Xanomeline, SIB-1553A, TC-1827
Collection: Muscarinic Agonists, Nitriles, Oximes, Quinuclidines
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
(3R)-N-methoxyquinuclidine-3-carboximidoyl cyanide hydrochloride
Clinical data
Legal status
  • Never marketed
CAS number
ATC code None
IUPHAR ligand
Chemical data
Formula C10H15N3O 
Mol. mass 193.12 g/mol

Sabcomeline (Memric; SB-202,026) is a selective M1 receptor partial agonist that was under development for the treatment of Alzheimer's disease.[1] It made it to phase III clinical trials before being discontinued due to poor results.

See also


  1. ^ Loudon JM, Bromidge SM, Brown F, et al. (December 1997). "SB 202026: a novel muscarinic partial agonist with functional selectivity for M1 receptors". The Journal of Pharmacology and Experimental Therapeutics 283 (3): 1059–68.  

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