Somatostatin receptor 5

Somatostatin receptor 5
Symbols  ; SS-5-R
External IDs IUPHAR: ChEMBL: GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Somatostatin receptor type 5 is a protein that in humans is encoded by the SSTR5 gene.[1] Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR5 is a member of the superfamily of receptors having seven transmembrane segments.[2]

See also


  1. ^ Takeda J, Fernald AA, Yamagata K, Le Beau MM, Bell GI (Aug 1995). "Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization". Genomics 26 (3): 638–9. PMID 7607700. doi:10.1016/0888-7543(95)80195-R. 
  2. ^ "Entrez Gene: SSTR5 somatostatin receptor 5". 

Further reading

  • Yamada Y, Post SR, Wang K, et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. PMC 48214. PMID 1346068. doi:10.1073/pnas.89.1.251. 
  • Montminy MR, Goodman RH, Horovitch SJ, Habener JF (1984). "Primary structure of the gene encoding rat preprosomatostatin.". Proc. Natl. Acad. Sci. U.S.A. 81 (11): 3337–40. PMC 345502. PMID 6145156. doi:10.1073/pnas.81.11.3337. 
  • Panetta R, Greenwood MT, Warszynska A, et al. (1994). "Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28.". Mol. Pharmacol. 45 (3): 417–27. PMID 7908405. 
  • O'Carroll AM, Raynor K, Lolait SJ, Reisine T (1994). "Characterization of cloned human somatostatin receptor SSTR5.". Mol. Pharmacol. 46 (2): 291–8. PMID 8078491. 
  • Yamada Y, Kagimoto S, Kubota A, et al. (1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.". Biochem. Biophys. Res. Commun. 195 (2): 844–52. PMID 8373420. doi:10.1006/bbrc.1993.2122. 
  • Yamada Y, Stoffel M, Espinosa R, et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms.". Genomics 15 (2): 449–52. PMID 8449518. doi:10.1006/geno.1993.1088. 
  • Fukusumi S, Kitada C, Takekawa S, et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide.". Biochem. Biophys. Res. Commun. 232 (1): 157–63. PMID 9125122. doi:10.1006/bbrc.1997.6252. 
  • Ain KB, Taylor KD, Tofiq S, Venkataraman G (1997). "Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines.". J. Clin. Endocrinol. Metab. 82 (6): 1857–62. PMID 9177396. doi:10.1210/jc.82.6.1857. 
  • de Lecea L, Ruiz-Lozano P, Danielson PE, et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.". Genomics 42 (3): 499–506. PMID 9205124. doi:10.1006/geno.1997.4763. 
  • Jaïs P, Terris B, Ruszniewski P, et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.". Eur. J. Clin. Invest. 27 (8): 639–44. PMID 9279525. doi:10.1046/j.1365-2362.1997.1740719.x. 
  • Hukovic N, Panetta R, Kumar U, et al. (1998). "The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization.". J. Biol. Chem. 273 (33): 21416–22. PMID 9694905. doi:10.1074/jbc.273.33.21416. 
  • Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.". Mol. Endocrinol. 13 (1): 82–90. PMID 9892014. doi:10.1210/me.13.1.82. 
  • Kumar U, Sasi R, Suresh S, et al. (1999). "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.". Diabetes 48 (1): 77–85. PMID 9892225. doi:10.2337/diabetes.48.1.77. 
  • Rocheville M, Lange DC, Kumar U, et al. (2000). "Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers.". J. Biol. Chem. 275 (11): 7862–9. PMID 10713101. doi:10.1074/jbc.275.11.7862. 
  • Rocheville M, Lange DC, Kumar U, et al. (2000). "Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity.". Science 288 (5463): 154–7. PMID 10753124. doi:10.1126/science.288.5463.154. 
  • Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339–52. PMID 11157797. doi:10.1093/hmg/10.4.339. 
  • Ballarè E, Persani L, Lania AG, et al. (2001). "Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment.". J. Clin. Endocrinol. Metab. 86 (8): 3809–14. PMID 11502816. doi:10.1210/jc.86.8.3809. 
  • Pasquali D, Notaro A, Esposito D, et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID 11753241. 
  • Papotti M, Bongiovanni M, Volante M, et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis.". Virchows Arch. 440 (5): 461–75. PMID 12021920. doi:10.1007/s00428-002-0609-x. 

External links

  • "5"Somatostatin Receptors: sst. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  • somatostatin receptor 5 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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