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Sticky platelet syndrome

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Title: Sticky platelet syndrome  
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Subject: Nutritional anemia, Delta-thalassemia, Hexokinase deficiency, Hereditary persistence of fetal hemoglobin, Congenital amegakaryocytic thrombocytopenia
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Sticky platelet syndrome

Sticky platelet syndrome is a term used by some[1][2][3][4] to describe a disorder of platelet function.[5] It was first described by Mammen in 1983.[6] It is inherited in an autosomal dominant pattern.[7] It has not been associated with a specific gene, and it is not recognized as an entity in OMIM.

Among researchers using the term, it has been described as a coagulation disorder that can present in conjunction with protein S deficiency and Factor V Leiden.[8] It is not currently known if sticky platelet syndrome is a distinct condition, or if it represents part of the presentation of a more well characterized coagulation disorder.


SPS is diagnosed by demonstrating platelet hyperaggregability. In a lab test called aggregometry platelet stickyness is stimulated with epinephrine (EPI) and/or adenosine diphosphate (ADP).[9] This test is not possible for patients being treated with acetylsalicylic acid until that substance has sufficiently cleared from their system.


Those diagnosed are usually treated with taking a low dose (80–100 mg) Aspirin a day.[10] Anticoagulants (e.g. Warfarin, Coumadin) or clopidogrel (Plavix) are often additionally prescribed following formation of a medically significant clot. Thrombelastography is more commonly being used to diagnose hypercoagulability and monitor anti-platelet therapy.


Critics of the diagnosis complain that case evidence is spotty and lacking controlled clinical studies.[11]


  1. ^ Mammen EF (1999). "Sticky platelet syndrome". Semin. Thromb. Hemost. 25 (4): 361–5.  
  2. ^ Frenkel EP, Mammen EF (February 2003). "Sticky platelet syndrome and thrombocythemia". Hematol. Oncol. Clin. North Am. 17 (1): 63–83.  
  3. ^ Mears KA, Van Stavern GP (July 2008). "Bilateral Simultaneous Anterior Ischaemic Optic Neuropathy Associated with Sticky Platelet Syndrome". Br J Ophthalmol 93 (7): 885–6, 913.  
  4. ^ Mammen EF, Barnhart MI, Selik NR, Gilroy J, Klepach GL (1988). ""Sticky platelet syndrome": a congenital platelet abnormality predisposing to thrombosis?". Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. 115 (3): 361–5.  
  5. ^ Mühlfeld AS, Ketteler M, Schwamborn K, et al (July 2007). "Sticky platelet syndrome: an underrecognized cause of graft dysfunction and thromboembolic complications in renal transplant recipients". Am. J. Transplant. 7 (7): 1865–8.  
  6. ^ Bick, Rodger L (2006). Hematological complications in obstetrics, pregnancy, and gynecology. Cambridge, UK: Cambridge University Press. p. 147.  
  7. ^ McKay, Robert; David R. Gambling (2008). Obstetric anesthesia and uncommon disorders. Cambridge, UK: Cambridge University Press. p. 308.  
  8. ^ Chaturvedi S, Dzieczkowski JS (1999). "Protein S deficiency, activated protein C resistance and sticky platelet syndrome in a young woman with bilateral strokes". Cerebrovasc. Dis. 9 (2): 127–30.  
  9. ^
  10. ^ Mammen EF (1999). "Sticky platelet syndrome". Semin. Thromb. Hemost. 25 (4): 361–5.  
  11. ^

See also

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