World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0000860897
Reproduction Date:

Title: Tetrahydrozoline  
Author: World Heritage Encyclopedia
Language: English
Subject: Alpha-1 adrenergic receptor, Broxaterol, Mivazerol, Mabuterol, Zinterol
Publisher: World Heritage Encyclopedia


CAS number  N
ChemSpider  YesY
ATC code R01,S01
Jmol-3D images Image 1
Molecular formula C13H16N2
Molar mass 200.28 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N   YesY/N?)

Tetrahydrozoline (INN: Tetryzoline), a derivative of imidazoline, is found in over-the-counter eye drops and nasal sprays. Other derivatives include naphazoline, oxymetazoline, and xylometazoline.

Tetrahydrozoline is an alpha agonist and its main mechanism of action is the constriction of conjunctival blood vessels.[1] This serves to relieve the redness of the eye caused by minor ocular irritants.

An urban legend suggests that tetrahydrozoline can cause violent diarrhea if administered orally, such as by putting a few drops of Visine in an unsuspecting person's beverage. However, the actual results of the "Visine Prank" may be worse, varying from severe nausea and vomiting to seizures or a coma. Diarrhea is not a side effect.[2]


Tetrahydrozoline can be synthesized in one step by the heterocyclization of 1-cyanotetralin with ethylenediamine.[3]


  1. ^ Dahlström M, Lindgren F, Berntsson K et al. (July 2005). "Evidence for different pharmacological targets for imidazoline compounds inhibiting settlement of the barnacle Balanus improvisus". J. Exp. Zoolog. Part a Comp. Exp. Biol. 303 (7): 551–62.  
  2. ^ "Visine Prank: Mickey Red Eyes". Snopes. 29 June 2009. Retrieved 28 July 2010. 
  3. ^ M. E. Synerholm, L. H. Jules, M. Sahyun, U.S. Patent 2,731,471 (1956)

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.