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Title: Tioconazole  
Author: World Heritage Encyclopedia
Language: English
Subject: Cyanoketone, Metyrapone, 22R-Hydroxycholesterol, 20α,22R-Dihydroxycholesterol, Cyproterone acetate
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Trade names Vagistat-1
Legal status
Routes of
CAS Registry Number  YesY
ATC code D01 G01
PubChem CID:
DrugBank  N
ChemSpider  N
Synonyms Thioconazole
Chemical data
Formula C16H13Cl3N2OS
Molecular mass


Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by a fungus or yeast. It is marketed under the brand names Trosyd and Gyno-Trosyd (Pfizer). Tioconazole ointments serve to treat women's vaginal yeast infections.[1] They are available in one day doses, as opposed to the 7-day treatments more common in use in the past.

Tioconazole topical (skin) preparations are also available for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus".

Side effects

Side effects (for the women's formulas) may include temporary burning/irritation of the vaginal area, moderate drowsiness, headache similar to a sinus headache, hives, and upper respiratory infection. These side effects may be only temporary, and do not normally interfere with the patient's comfort enough to outweigh the end result.


Antimycotic imidazole derivative.

Tiaconazole synthesis:[2]

A displacement reaction between 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol and 2-chloro-3-(chloromethyl)thiophene is performed.

See also


  1. ^ Tioconazole, Mayo Clinic
  2. ^ G. E. Gymer, BE 841309 ; idem, U.S. Patent 4,062,966 (1976, 1977 both to Pfizer).
  3. ^

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