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Triazole

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Title: Triazole  
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Subject: Clicked peptide polymer, Persistent carbene, Fluconazole, Itraconazole, ATC code D01
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Triazole

A triazole (Htrz) refers to any of the heterocyclic compounds with molecular formula C2H3N3, having a five-membered ring of two carbon atoms and three nitrogen atoms. There are two sets of isomers that differ in the relative positions of the three nitrogen atoms. Each of these has two tautomers that differ by which nitrogen has a hydrogen bonded to it:

Contents

  • Derivatives 1
  • Importance in agriculture 2
  • Importance in chemical synthesis 3
  • Related heterocycles 4
  • External links 5
  • References 6

Derivatives

The triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole.

The triazole plant protection fungicides include epoxiconazole, triadimenol, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.

Benzotriazole is used in chemical photography as a restrainer and fog-suppressant.

Importance in agriculture

Due to spreading resistance of plant pathogens towards fungicides of the strobilurin class,[1] control of fungi such as Septoria tritici or Gibberella zeae[2] relies heavily on triazoles. Food, like store bought potatoes, contain retardants such as triazole or tetcyclacis.[3]

Importance in chemical synthesis

The

  1. ^ Gisi U, Sierotzki H,Cook A, McCaffery A (2002): Mechanisms influencing the evolution of resistance to Qo inhibitor fungicides. Pest Management Science 58: 859–867. [1]
  2. ^ Klix MB, Verreet J-A, Beyer M (2007): Comparison of the declining triazole sensitivity of Gibberella zeae and increased sensitivity achieved by advances in triazole fungicide development. Crop Protection 26:683-690. [2]
  3. ^ http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-16202009000200013
  4. ^ Hiroyuki Isobe et al. (2008) Triazole-Linked Analogue of Deoxyribonucleic Acid (TLDNA): Design, Synthesis, and Double-Strand Formation with Natural DNA, Org. Lett. 10 (17), pp 3729–3732.[3]

References


  • Synthesis of 1,2,3-triazoles (overview of recent methods)

External links

  • Imidazole, an analog with two nonadjacent nitrogen atoms
  • Pyrazole, an analog with two adjacent nitrogen atoms
  • Tetrazole, an analog with four nitrogen atoms

Related heterocycles

) [4]

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