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Title: Trional  
Author: World Heritage Encyclopedia
Language: English
Subject: Tetronal, Spirobarbital, Centalun, Proxibarbital, Reposal
Collection: Gabaa Receptor Positive Allosteric Modulators, Hypnotics
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
CAS Registry Number  N
ATC code None
PubChem CID:
ChemSpider  Y
Chemical data
Formula C8H18O4S2
Molecular mass 242.356 g/mol

Trional (Methylsulfonal) is a sedative-hypnotic[1] and anesthetic drug with GABAergic actions. It has similar effects to sulfonal, except it is faster acting.[2]


Trional was prepared and introduced by Eugen Baumann and Alfred Kast in 1888.[3]

Appeared in Agatha Christie's "Murder On The Orient Express", "And Then There Were None" and other novels as a sleep inducing sedative, and in In Search of Lost Time (Sodom and Gomorrah) by Marcel Proust as an hypnotic.

See also


  1. ^ (1907). Merck's 1907 Index. N. Y.: Merck & Co., p. 448.
  2. ^ Sajous, Charles E. (1896). Annual of the Universal Medical Sciences
    Philadelphia: F. A. Davis, v. 5, p. A-156.
  3. ^ Drinkwater, H. (1924). Fifty years of medical progress, 1873-1922.
    New York: The Macmillan Company, p. 40.

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