World Library  
Flag as Inappropriate
Email this Article

Way-208,466

Article Id: WHEBN0026757779
Reproduction Date:

Title: Way-208,466  
Author: World Heritage Encyclopedia
Language: English
Subject: 5-HT6 receptor, WAY-181,187, RS-56812, BRL-54443, MPPF
Collection: Chloroarenes, Hydrazides, Organochlorides, Pyrazines, Serotonin Receptor Agonists, Thiazoles
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Way-208,466

WAY-208,466
Systematic (IUPAC) name
N'-[(2Z)-4-(2,4-dichlorophenyl)-3-(2-methylpropyl)-1,3-thiazol-2(3H)-ylidene]-2-(pyrazin-2-yloxy)acetohydrazide
Clinical data
Legal status
?
Identifiers
CAS number
ATC code None
PubChem
ChemSpider
ChEMBL
Chemical data
Formula C19H19Cl2N5O2S 
Mol. mass 452.36 g/mol

WAY-208,466 is a potent and highly selective full agonist of the 5-HT6 receptor.[1] It increases GABA levels in the cerebral cortex and tolerance does not appear to occur to this action upon chronic administration.[1] Animal studies have shown that WAY-208,466 produces antidepressant and anxiolytic effects in rodents and it may also be useful in the treatment of obsessive-compulsive disorder.[1][2]

See also

References

  1. ^ a b c Schechter LE, Lin Q, Smith DL, et al. (May 2008). "Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466". Neuropsychopharmacology 33 (6): 1323–35.  
  2. ^ Carr GV, Schechter LE, Lucki I (March 2010). "Antidepressant and anxiolytic effects of selective 5-HT(6) receptor agonists in rats". Psychopharmacology 213 (2–3): 499–507.  
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.