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Xylamidine

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Title: Xylamidine  
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Subject: 5-HT1A receptor, RS-56812, MPPF, 9-Aminomethyl-9,10-dihydroanthracene, 6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide
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Xylamidine

Xylamidine
Systematic (IUPAC) name
N'-[2-(3-methoxyphenoxy)propyl]-2-(3-methylphenyl)ethanimidamide
Clinical data
Legal status
?
Identifiers
CAS number
ATC code None
PubChem
ChemSpider
UNII  YesY
Chemical data
Formula C19H24N2O2 
Mol. mass 312.406 g/mol
 YesY   

Xylamidine is a drug which acts as an antagonist at the 5HT2A receptor, and to a lesser extent at the 5HT1A receptor. It does not cross the blood brain barrier which makes it useful for blocking peripheral serotonergic responses like cardiovascular[1][2] and gastrointestinal effects,[3] without producing the central effects of 5HT2A blockade such as sedation, or interfering with the central actions of 5HT2A agonists.[4]

References

  1. ^ Fuller, RW; Kurz, KD; Mason, NR; Cohen, ML (1986). "Antagonism of a peripheral vascular but not an apparently central serotonergic response by xylamidine and BW 501C67".  
  2. ^ Dedeoğlu, A; Fisher, LA (1991). "Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms". The Journal of Pharmacology and Experimental Therapeutics 259 (3): 1027–34.  
  3. ^ Baker, BJ; Duggan, JP; Barber, DJ; Booth, DA (1988). "Effects of dl-fenfluramine and xylamidine on gastric emptying of maintenance diet in freely feeding rats". European Journal of Pharmacology 150 (1–2): 137–42.  
  4. ^ Dave, KD; Quinn, JL; Harvey, JA; Aloyo, VJ (2004). "Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit". Pharmacology, Biochemistry, and Behavior 77 (3): 623–9.  


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