World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0022234107
Reproduction Date:

Title: Zalospirone  
Author: World Heritage Encyclopedia
Language: English
Subject: NBUMP, Revospirone, Quipazine, Adatanserin, WAY-100,135
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
  • Uncontrolled
Routes Oral
Pharmacokinetic data
Half-life 1-4 hours
CAS number
ATC code None
IUPHAR ligand
Chemical data
Formula C24H29N5O2 
Mol. mass 419.519 g/mol

Zalospirone (WY-47,846) is a selective 5-HT1A partial agonist of the azapirone chemical class.[1][2] It was found to be effective in the treatment of anxiety and depression in clinical trials, but a high proportion of subjects dropped out due to side effects and development was subsequently never completed.[3]

See also


  1. ^ Gleeson, S; Barrett, JE (1990). "5-HT1A agonist effects on punished responding of squirrel monkeys". Pharmacology, Biochemistry, and Behavior 37 (2): 335–7.  
  2. ^ Singh, A; Lucki, I (1993). "Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors". Neuropharmacology 32 (4): 331–40.  
  3. ^ Rickels, K; Derivan, A; Kunz, N; Pallay, A; Schweizer, E (1996). "Zalospirone in major depression: a placebo-controlled multicenter study". Journal of Clinical Psychopharmacology 16 (3): 212–7.  

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.