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Zalospirone

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Zalospirone

Zalospirone
Systematic (IUPAC) name
(3aα,4α,4aβ,6aβ,7α,7aα)-hexahydro-2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-4,7-etheno-1H-cyclobut(f)isoindole-1,3(2H)-dione
Clinical data
Legal status
  • Uncontrolled
Routes Oral
Pharmacokinetic data
Half-life 1-4 hours
Identifiers
CAS number
ATC code None
PubChem
IUPHAR ligand
ChemSpider
UNII  YesY
Chemical data
Formula C24H29N5O2 
Mol. mass 419.519 g/mol
 YesY   

Zalospirone (WY-47,846) is a selective 5-HT1A partial agonist of the azapirone chemical class.[1][2] It was found to be effective in the treatment of anxiety and depression in clinical trials, but a high proportion of subjects dropped out due to side effects and development was subsequently never completed.[3]

See also

References

  1. ^ Gleeson, S; Barrett, JE (1990). "5-HT1A agonist effects on punished responding of squirrel monkeys". Pharmacology, Biochemistry, and Behavior 37 (2): 335–7.  
  2. ^ Singh, A; Lucki, I (1993). "Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors". Neuropharmacology 32 (4): 331–40.  
  3. ^ Rickels, K; Derivan, A; Kunz, N; Pallay, A; Schweizer, E (1996). "Zalospirone in major depression: a placebo-controlled multicenter study". Journal of Clinical Psychopharmacology 16 (3): 212–7.  


5-HT1A agonists
GABAAR PAMs
α2δ VDCC blockers
Antidepressants
Sympatholytics
Others

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