Influence of Exposure Concentration or Dose on the Distribution of Particulate Material in Rat and Human Lungs

By Nikula, Kristen J.

Book Id: WPLBN0000164726
Format Type: PDF eBook
File Size: 0.2 MB
Reproduction Date: 2005

Title:	Influence of Exposure Concentration or Dose on the Distribution of Particulate Material in Rat and Human Lungs
Author:	Nikula, Kristen J.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago Nikula, K. J. (n.d.). Influence of Exposure Concentration or Dose on the Distribution of Particulate Material in Rat and Human Lungs. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: The scientific and regulatory communities are concerned about potential neoplastic and non-neoplastic health effects of inhaled particles in humans. To date, much of the experimental data on chronic health effects of inhaled particles come from rats. However, an interspecies difference in response, with rats but not mice showing an increased incidence of lung tumors, has been shown for a number of relatively insoluble particles [reviewed by Nikula (1)] including talc (2), carbon black (3), titanium dioxide (3), silica (4), nickel subsulfide (5), cadmium sulfate (6,7), cadmium sulfide (6,7), and cadmium chloride (6,7). Several chronic inhalation bioassays of diesel exhaust in rats, Syrian hamsters, and mice have been conducted [reviewed by Nikula (1)]. These bioassays have consistently shown that diesel exhaust, inhaled chronically at high concentrations, causes increased incidences of lung tumors in rats.