World Health Organization : Year 2004 ; The Special Programme for Research and Training in Tropical Diseases Swg 04: Report of the Scientific Working Group Meeting on Leishmaniasis

By World Health Organization

Book Id: WPLBN0000168650
Format Type: PDF eBook
File Size: 2.5 MB
Reproduction Date: 2005

Title:	World Health Organization : Year 2004 ; The Special Programme for Research and Training in Tropical Diseases Swg 04: Report of the Scientific Working Group Meeting on Leishmaniasis
Author:	World Health Organization
Volume:
Language:	English
Subject:	Health., Public health, Wellness programs
Collections:	Medical Library Collection, World Health Collection
Historic Publication Date:
Publisher:	World Health Organization


Citation APA MLA Chicago Organization, W. H. (n.d.). World Health Organization : Year 2004 ; The Special Programme for Research and Training in Tropical Diseases Swg 04. Retrieved from http://self.gutenberg.org/

Description
Medical Reference Publication

Excerpt
1. Rationale for convening the Scientific Working Group on Leishmaniasis The goal of the Scientific Working Group (SWG) meeting was to identify leishmaniasis research priorities for the next five years. In addition, the group was to identify strategic emphases, based on TDR’s comparative advantage, to add to the current ones. The discussions were to be focused on how to cope with and prevent drug resistance, and how to optimize the use of genomic information to improve drug, diagnostics and vaccine discovery. Additionally, the group was requested to consider if leishmaniasis should remain on the list of TDR category I diseases (emerging and uncontrolled; worsening epidemiological situation; increasing incidence of infection and disease).

Table of Contents
Contents 1. Rationale for convening the Scientific Working Group on Leishmaniasis . . . . . . 1 2. Recommendations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 4. Generating evidence to improve the effectiveness of control programmes . . . . 7 IMPROVED DIAGNOSTIC TOOLS AND STRATEGIES FOR VISCERAL LEISHMANIASIS . . . . . . . . . . . 7 IMPROVED THERAPIES AND PATIENT MANAGEMENT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 IMPROVED PREVENTION STRATEGIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 PARTNERSHIPS AND CAPACITY BUILDING . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 2. Challenges and opportunities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 CHALLENGES POSED BY GAPS IN BASIC KNOWLEDGE AND LIMITATIONS OF CURRENT TOOLS . . 13 RESEARCH OPPORTUNITIES TO CLOSE THE GAPS IN BASIC KNOWLEDGE AND TO DEVELOP NEW TOOLS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 3. High priorities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 INTERVENTION METHODS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 STRATEGIES & POLICIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 PARTNERSHIPS & CAPACITY BUILDING . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 BASIC KNOWLEDGE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 NEW AND IMPROVED TOOLS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Annex 1. AGENDA: Scientific Working Group on Leishmaniasis . . . . . . . . . . . . . . . 19 Annex 2. LIST OF PARTICIPANTS: Scientific Working Group on Leishmaniasis. . . . 23 Annex 3. STRATEGIC RESEARCH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 3.1 FROM GENOME TO DISCOVERY IN LEISHMANIA: RECOMMENDATIONS FOR THE DEVELOPMENT OF DRUGS, VACCINES AND DIAGNOSTICS . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 3.2 DRUG RESISTANCE IN LEISHMANIASIS (SUMMARY) . . . . . . . . . . . . . . . . . . . . . . . . . . 33 3.3 HOST GENETICS IN LEISHMANIASIS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 3.4 MECHANISMS OF PATHOGENESIS – DIFFERENCES AMONGST LEISHMANIA SPECIES . . . . . . 37 3.5 CELLULAR IMMUNE RESPONSES (SUMMARY) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 3.6 VECTOR–PARASITE AND VECTOR–HOST INTERACTIONS IN LEISHMANIASIS . . . . . . . . . . . 42 Annex 4. IMPROVED TOOLS AND INTERVENTION METHODS . . . . . . . . . . . . . . . . . . . . 45 4.1 VACCINES. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46 4.2 MOLECULAR TOOLS FOR STUDYING THE EPIDEMIOLOGY OF LEISHMANIASIS . . . . . . . . . . 54 4.3 DRUG TRIALS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71 4.4 CONTROL OF ZOONOTIC VISCERAL LEISHMANIASIS . . . . . . . . . . . . . . . . . . . . . . . . . . . 74 4.5 POST KALA-AZAR DERMAL LEISHMANIASIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 76 4.6 EPIDEMIOLOGY OF LEISHMANIA-HIV CO-INFECTIONS . . . . . . . . . . . . . . . . . . . . . . . . . . 79