Absorption, Metabolism, And Excretion of Di(2-Ethylhexyl) Phthalate by Rats and Mice

By Albro, Phillip W.

Book Id: WPLBN0000202636
Format Type: PDF eBook
File Size: 0.4 MB
Reproduction Date: 2005

Title:	Absorption, Metabolism, And Excretion of Di(2-Ethylhexyl) Phthalate by Rats and Mice
Author:	Albro, Phillip W.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago Albro, P. W. (n.d.). Absorption, Metabolism, And Excretion of Di(2-Ethylhexyl) Phthalate by Rats and Mice. Retrieved from http://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: Presently available evidence strongly suggests that the undesirable biological effects of phthalate esters are mediated by metabolites rather than by the parent compounds in viva. Such effects as testicular atrophy (1) and peroxisom proliiration in rodents (2) are also seen on administration of the primary hydrolysis products of phthalate esters (3-5). Effects produced by, e.g. di(2- ethylhexyl) phthalate (DEHP) on mitochondria1 function and energy metabolism in vivo are also produced (in vitro) by either muno-2-ethylhexyl phthalate or Z-ethylhexanol or their oxidation products (6,Y). Oral exposure to less than massive amounts of DEHP, the most thoroughly studied of the phthalate diesters, does not result in exposure of internal organs to intact diester since hydrolysis is very rapid in lung and intestines (8,9). The organs that are most likely to be exposed to high levels of intact phthalate diester-skin and gastrointestinal tract-are not considered target organs Eor adverse biological effects.