Summary of Carcinogenic Potency and Positivity for 492 Rodent Carcinogens in the Carcinogenic Potency Database

By Slone, Thomas H.

Book Id: WPLBN0000224186
Format Type: PDF eBook
File Size: 0.7 MB
Reproduction Date: 2005

Title:	Summary of Carcinogenic Potency and Positivity for 492 Rodent Carcinogens in the Carcinogenic Potency Database
Author:	Slone, Thomas H.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago Slone, T. H. (n.d.). Summary of Carcinogenic Potency and Positivity for 492 Rodent Carcinogens in the Carcinogenic Potency Database. Retrieved from http://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Introduction: For a variety of purposes it is desirable to have a summary measure of the carcinogenic potency of a chemical in rodents. A single value is needed, for example, to summarize the chronic toxicity of a chemical, to estimate carcinogenic hazards to humans by a comparison of rodent potency and human exposure (1,2), or to compare results of short-term tests with those of rodent bioassays (3). For several years we have been developing the Carcinogenic Potency Database (CPDB), a compilation of the results of chronic rodent cancer tests and the potency values derived from those results (4-6). The CPDB contains data on approximately 3700 experiments of 975 compounds, including tests from the National Cancer Institute and National Toxicology Program (NCI/ NTP), as well as from the general published literature. For a given compound, the database may include experiments in both rats and mice, males and females, a variety of strains or routes of administration, and a variety of doses and experimental conditions; alternatively, for a different substance there may be only one experiment conducted in a single sex-species group. In order to construct a chemical-by-chemical list of carcinogenic potency in each species, some.