The Role of the Thomsen-Friedenreich Antigen as a Tumor-Associated Molecule

By Dippold, Wolfgang

Book Id: WPLBN0000018544
Format Type: PDF eBook
File Size: 0.2 MB
Reproduction Date: 2005

Title:	The Role of the Thomsen-Friedenreich Antigen as a Tumor-Associated Molecule
Author:	Dippold, Wolfgang
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago Dippold, W. (n.d.). The Role of the Thomsen-Friedenreich Antigen as a Tumor-Associated Molecule. Retrieved from http://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Introduction: During carcinogenesis, alterations occur in the biosynthesis of carbohydrate structures on the cell surface. Therefore, carbohydrates linked either to proteins or lipids are recognized as tumor-associated molecules (1,Z). An interesting novel approach to achieve tumor immunity is to vaccinate patients with chemically synthesized glycopeptides that are restricted to tumors. Several investigators ($4)h ave succeeded in generating glycopeptides with Gal-GalNAc residues coupled to serine or threonine and bound to a carrier protein. This structure has long been known as the Thomsen-Friedenreich antigen (T-antigen) (5). The T-antigen was extensively studied by Springer and his colleagues (6) and believed to be tumor restricted. This antigen is the immediate precursor of the human blood group MN antigens, which are located in the NH,-terminal region of the major sialoglycoprotein (glycophorin A) of human erythrocytes. The immunodominant group of the T-antigen [pGal (1-3) uGalNAc] is described as a cryptic determinant on human erythrocytes, which is exposed by neuraminidase treatment. This unmasked form has been reported to be present on most human carcinomas.