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Germinal matrix hemorrhage

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Title: Germinal matrix hemorrhage  
Author: World Heritage Encyclopedia
Language: English
Subject: Germinal matrix, Neonatology, Neurotrauma, ICD-10 Chapter XVI: Certain conditions originating in the perinatal period, Echogenic intracardiac focus
Collection: Disorders Causing Seizures, Neonatology, Neurotrauma
Publisher: World Heritage Encyclopedia

Germinal matrix hemorrhage

Germinal matrix hemorrhage
Classification and external resources
ICD-10 P52
ICD-9-CM 772.11
eMedicine radio/305

Germinal matrix hemorrhage is a bleeding into the subependymal germinal matrix with or without subsequent rupture into the lateral ventricle.


  • Pathophysiology 1
  • Clinical features 2
  • Grades 3
  • Treatment 4
  • See also 5
  • References 6


The germinal matrix is the site of proliferating neuronal and glial precursors in the developing brain, which is located above the caudate nucleus, in the floor of the lateral ventricle, and caudothalamic groove. The germinal matrix contains a rich network of fragile thin-walled blood vessels. Hence the microcirculation in this particular area is extremely sensitive to hypoxia and changes in perfusion pressure. It is most frequent before 35 weeks gestation and is typically seen in very low birth-weight (<1500g) premature infants, because they lack the ability for auto regulation of cerebral blood flow. Consequently increased arterial blood pressure in these blood vessels leads to rupture and hemorrhage into germinal matrix.

Clinical features

This may lead to various neurological sequelae including presentation with cerebral palsy, mental retardation and seizures.


Four grades are distinguished (by imaging or histology):

  • grade I - hemorrhage is confined to the germinal matrix
  • grade II - intraventricular hemorrhage without ventricular dilatation
  • grade III - intraventricular hemorrhage with ventricular dilatation
  • grade IV - intraventricular rupture and hemorrhage into the surrounding white matter


Antenatal corticosteroids have a role in reducing incidence of germinal matrix hemorrhage in premature infants.

See also


  • Enzmann D, Murphy-Irwin K, Stevenson D, Ariagno R, Barton J, Sunshine P (1985). "The natural history of subependymal germinal matrix hemorrhage". Am J Perinatol 2 (2): 123–33.  
  • Papile LA, Burstein J,Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: A study of infants withbirth weight less than 1,500 gm. J Pediatr 1978;92:529-34.
  • Alan Leviton, Karl C. Kuban, Linda Van Marter, Marcello Pagano, and Elizabeth N. Allred. Antenatal Corticosteroids Appear to Reduce the Risk of Postnatal Germinal Matrix Hemorrhage in Intubated Low Birth Weight Newborns Pediatrics, Jun 1993; 91: 1083 - 1088.
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