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Title: Rcs-4  
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Subject: JWH-018, MAM-2201, UR-144, CP 55,244, JWH-081
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Systematic (IUPAC) name
Clinical data
Legal status
CAS Registry Number  N
ChemSpider  YesY
Chemical data
Formula C21H23NO2
Molecular mass 321.413 g/mol

RCS-4, or 1-pentyl-3-(4-methoxybenzoyl)indole, is a synthetic cannabinoid drug sold under the names SR-19, BTM-4, or Eric-4 (later shortened to E-4), but originally, OBT-199.


RCS-4 is a potent cannabinoid receptor agonist, with EC50 values of 146 nM for human CB1 receptors, and 46 nM for human CB2 receptors.[2] All methoxyphenyl regiosiomers, and N-butyl homologues of RCS-4 and its regiosiomers also display potent agonist activities at CB1 and CB2 receptors.[2]


RCS-4 was banned in Sweden on 1 October 2010 as a hazardous good harmful to health, after being identified as an ingredient in "herbal" synthetic cannabis products.[3][4]

It was outlawed in Denmark on 11 March 2011.[5]

In August 2011, New Zealand added not only RCS-4 but also its 1-butyl homologue, and the 2-methoxybenzoyl isomers of both these compounds, to a temporary class drug schedule (i.e. equivalent to Class C but reviewed after 12 months, and with personal possession and use of small amounts decriminalised), which was newly created under the Misuse of Drugs Amendment Act 2011 passed a week earlier.[6][7][8]

As of October 2015 RCS-4 is a controlled substance in China.[9]

RCS-4 and related analogues detected in synthetic cannabis blends

See also


  1. ^
  2. ^ a b
  3. ^ Swedish Code of Statutes Regulation (2010:1086).
  4. ^ Swedish Code of Statutes Regulation (2010:1086). (pdf)
  5. ^
  6. ^
  7. ^
  8. ^ New Zealand Gazette. Tuesday 9 August 2011. Issue No 122, pp 3365-3366. Departmental Notices. Health. Misuse of Drugs Act 1975. Temporary Class Drug Notice.
  9. ^

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