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Tolfenamic acid

 

Tolfenamic acid

Tolfenamic acid
Systematic (IUPAC) name
2-[(3-chloro-2-methylphenyl)amino]benzoic acid)[1]
Clinical data
AHFS/Drugs.com
Legal status
Routes of
administration
oral
Identifiers
CAS Registry Number  N
ATC code M01
PubChem CID:
ChemSpider  Y
UNII  N
KEGG  Y
ChEBI  N
ChEMBL  Y
Chemical data
Formula C14H12ClNO2
Molecular mass 261.707 g/mol
 N   

Tolfenamic acid (Clotam) is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs discovered by scientists at Medica Pharmaceutical Company in Finland.[2] Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins.[3]

It is used in the UK as a treatment for migraine.[4] It is generally not available in the US.[3] It is available in some Asian, Latin American and European countries as a generic drug for humans and for animals.[5]

References

  1. ^ Kim Vilbour Andersen, Sine Larsen, Børge Alhede, Niels Gelting and Ole Buchardt (1989). = P29890001443 "Characterization of two polymorphic forms of tolfenamic acid, N-(2-methyl-3-chlorophenyl)anthranilic acid: their crystal structures and relative stabilities" . J. Chem. Soc., Perkin Trans. 2 (10): 1443–1447.  
  2. ^ Pentikäinen PJ, et al Human pharmacokinetics of tolfenamic acid, a new anti-inflammatory agent. Eur J Clin Pharmacol. 1981;19(5):359-65. PMID 7238564
  3. ^ a b NIH LiverTox Database Mefenamic Acid Last updated June 23, 2015. Page accessed July 3, 2015. Quote: "(fenamates generally not available in the United States, such as tolfenamic acid and flufenamic acid)"
  4. ^ NHS Tolfenamic Acid (Tolfenamic acid 200mg tablets) Page accessed July 3, 2015
  5. ^ Drugs.com Drugs.com international listings for tolfenamic acid Page accessed July 3, 2015

External links

  • Tolfenamic acid information (Diseases Database)
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