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Title: Mequinol  
Author: World Heritage Encyclopedia
Language: English
Subject: Butylated hydroxyanisole, ATC code D11, C7H8O2
Publisher: World Heritage Encyclopedia


Mequinol is a drug used in combination with the drug tretinoin in the treatment of liver spots.[1] Mequinol used alone and in higher doses is used as a topical drug for medical depigmentation.


It is the monomethyl ether of hydroquinone, and an isomer of guaiacol.

It is often used to inhibit polymerization in monomers that polymerize with radical mechanisms, such as acrylates, methacrylates or styrene.


A combination of mequinol 2% (depigmentation agent) & tretinoin 0.01% (topical retinoid) is commonly used in treating solar lentigines (liver spots & age spots). Exactly how it works is unknown, but this compound is used along with a total skin care and sunlight avoidance program. This compound may also be used for other conditions as determined by one's dermatologist. Methoxyphenol is a depigmentation agent, like Monobenzone (benzyloxyphenol), it is the active ingredient in some depigmenting creams and ointments. A formulation of 20% 4-methoxyphenol ointment causes depigmentation in animal tissue.[2]

Lower dosages of topical mequinol and the Q-switched Ruby Laser[3] have been used to depigment normal skin in vitiligo patients with disseminated (greater than 50 percent of body surface area) idiopathic vitiligo.


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